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BMCBI
2011
13 years 2 months ago
DoBo: Protein domain boundary prediction by integrating evolutionary signals and machine learning
Background: Accurate identification of protein domain boundaries is useful for protein structure determination and prediction. However, predicting protein domain boundaries from a...
Jesse Eickholt, Xin Deng, Jianlin Cheng
BMCBI
2007
120views more  BMCBI 2007»
13 years 7 months ago
Quantitative sequence-function relationships in proteins based on gene ontology
Background: The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs share function...
Vineet Sangar, Daniel J. Blankenberg, Naomi Altman...
BMCBI
2008
135views more  BMCBI 2008»
13 years 7 months ago
Functional site prediction selects correct protein models
Background: The prediction of protein structure can be facilitated by the use of constraints based on a knowledge of functional sites. Without this information it is still possibl...
Vijayalakshmi Chelliah, William R. Taylor
BMCBI
2005
94views more  BMCBI 2005»
13 years 7 months ago
Measuring similarities between transcription factor binding sites
Background: Collections of transcription factor binding profiles (Transfac, Jaspar) are essential to identify regulatory elements in DNA sequences. Subsets of highly similar profi...
Szymon M. Kielbasa, Didier Gonze, Hanspeter Herzel
BMCBI
2008
131views more  BMCBI 2008»
13 years 7 months ago
CoCoNUT: an efficient system for the comparison and analysis of genomes
Background: Comparative genomics is the analysis and comparison of genomes from different species. This area of research is driven by the large number of sequenced genomes and hea...
Mohamed Ibrahim Abouelhoda, Stefan Kurtz, Enno Ohl...