The problem of discovering novel motifs of binding sites is important to the understanding of gene regulatory networks. Motifs are generally represented by matrices (PWM or PSSM) o...
Abstract-- Modeling the intermolecular reactions in a single cell is a critical problem in computational biology. Biochemical reaction systems often involve species in both low and...
Background: Next-generation sequencing technologies allow researchers to obtain millions of sequence reads in a single experiment. One important use of the technology is the seque...
Daniel MacLean, Vincent Moulton, David J. Studholm...
Background: High complexity is considered a hallmark of living systems. Here we investigate the complexity of temporal gene expression patterns using the concept of Permutation En...
Xiaoliang Sun, Yong Zou, Victoria J. Nikiforova, J...
Background: Microarray co-expression signatures are an important tool for studying gene function and relations between genes. In addition to genuine biological co-expression, corr...