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BMCBI
2010
201views more  BMCBI 2010»
13 years 7 months ago
Analysis of X-ray Structures of Matrix Metalloproteinases via Chaotic Map Clustering
Background: Matrix metalloproteinases (MMPs) are well-known biological targets implicated in tumour progression, homeostatic regulation, innate immunity, impaired delivery of pro-...
Ilenia Giangreco, Orazio Nicolotti, Angelo Carotti...
BMCBI
2010
139views more  BMCBI 2010»
13 years 7 months ago
A global optimization algorithm for protein surface alignment
Background: A relevant problem in drug design is the comparison and recognition of protein binding sites. Binding sites recognition is generally based on geometry often combined w...
Paola Bertolazzi, Concettina Guerra, Giampaolo Liu...
BMCBI
2008
133views more  BMCBI 2008»
13 years 7 months ago
MS-DOCK: Accurate multiple conformation generator and rigid docking protocol for multi-step virtual ligand screening
Background: The number of protein targets with a known or predicted tri-dimensional structure and of drug-like chemical compounds is growing rapidly and so is the need for new the...
Nicolas Sauton, David Lagorce, Bruno O. Villoutrei...
BMCBI
2007
153views more  BMCBI 2007»
13 years 7 months ago
Can Clustal-style progressive pairwise alignment of multiple sequences be used in RNA secondary structure prediction?
Background: In ribonucleic acid (RNA) molecules whose function depends on their final, folded three-dimensional shape (such as those in ribosomes or spliceosome complexes), the se...
Amelia B. Bellamy-Royds, Marcel Turcotte
BMCBI
2008
167views more  BMCBI 2008»
13 years 7 months ago
Not proper ROC curves as new tool for the analysis of differentially expressed genes in microarray experiments
Background: Most microarray experiments are carried out with the purpose of identifying genes whose expression varies in relation with specific conditions or in response to enviro...
Stefano Parodi, Vito Pistoia, Marco Muselli