Background: Whole-genome sequencing projects are rapidly producing an enormous number of new sequences. Consequently almost every family of proteins now contains hundreds of membe...
Background: Detecting homology between remotely related protein families is an important problem in computational biology since the biological properties of uncharacterized protei...
In our recent work, a new approach to establish sequence relatedness, by walking through the protein sequence space, was introduced. The sequence space is built from 20 amino acid...
P2CS (http://www.p2cs.org) is a specialized database for prokaryotic two-component systems (TCSs), virtually ubiquitous signalling proteins which regulate a wide range of physiolo...
Mohamed Barakat, Philippe Ortet, David E. Whitwort...
- The activities and function of proteins can potentially be determined by protein sequence motifs. Therefore, obtaining the universally conserved and crossed protein family bounda...