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» Shotgun Protein Sequencing
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ALMOB
2006
106views more  ALMOB 2006»
13 years 10 months ago
Multiple sequence alignment with user-defined anchor points
Background: Automated software tools for multiple alignment often fail to produce biologically meaningful results. In such situations, expert knowledge can help to improve the qua...
Burkhard Morgenstern, Sonja J. Prohaska, Dirk P&ou...
BMCBI
2005
81views more  BMCBI 2005»
13 years 10 months ago
Evolutionary sequence analysis of complete eukaryote genomes
Background: Gene duplication and gene loss during the evolution of eukaryotes have hindered attempts to estimate phylogenies and divergence times of species. Although current meth...
Jaime E. Blair, Prachi Shah, S. Blair Hedges
BMCBI
2004
196views more  BMCBI 2004»
13 years 10 months ago
MUSCLE: a multiple sequence alignment method with reduced time and space complexity
Background: In a previous paper, we introduced MUSCLE, a new program for creating multiple alignments of protein sequences, giving a brief summary of the algorithm and showing MUS...
Robert C. Edgar
NLDB
2005
Springer
14 years 3 months ago
Combining Biological Databases and Text Mining to Support New Bioinformatics Applications
Abstract. A large amount of biological knowledge today is only available from full-text research papers. Since neither manual database curators nor users can keep up with the rapid...
René Witte, Christopher J. O. Baker
BMCBI
2007
102views more  BMCBI 2007»
13 years 10 months ago
A comprehensive system for evaluation of remote sequence similarity detection
Background: Accurate and sensitive performance evaluation is crucial for both effective development of better structure prediction methods based on sequence similarity, and for th...
Yuan Qi, Ruslan Sadreyev, Yong Wang, Bong-Hyun Kim...