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CSB
2003
IEEE
108views Bioinformatics» more  CSB 2003»
14 years 1 months ago
A Pattern Matching Algorithm for Codon Optimization and CpG Motif-Engineering in DNA Expression Vectors
Codon optimization enhances the efficiency of DNA expression vectors used in DNA vaccination and gene therapy by increasing protein expression. Additionally, certain nucleotide mo...
Ravi Vijaya Satya, Amar Mukherjee, Udaykumar Ranga
CORR
2010
Springer
157views Education» more  CORR 2010»
13 years 7 months ago
Efficient Clustering with Limited Distance Information
Given a point set S and an unknown metric d on S, we study the problem of efficiently partitioning S into k clusters while querying few distances between the points. In our model ...
Konstantin Voevodski, Maria-Florina Balcan, Heiko ...
APBC
2004
122views Bioinformatics» more  APBC 2004»
13 years 9 months ago
Evolution of Relative Synonymous Codon Usage in Human Immunodeficiency Virus Type 1
Mutation in HIV-1 is extremely rapid, a consequence of a low-fidelity viral reverse transcription process. The envelope gene has been shown to accumulate substitutions at a rate o...
Peter L. Meintjes, Allen G. Rodrigo
BMCBI
2008
143views more  BMCBI 2008»
13 years 7 months ago
Automatic detection of exonic splicing enhancers (ESEs) using SVMs
Background: Exonic splicing enhancers (ESEs) activate nearby splice sites and promote the inclusion (vs. exclusion) of exons in which they reside, while being a binding site for S...
Britta Mersch, Alexander Gepperth, Sándor S...
BMCBI
2006
172views more  BMCBI 2006»
13 years 7 months ago
BioWarehouse: a bioinformatics database warehouse toolkit
Background: This article addresses the problem of interoperation of heterogeneous bioinformatics databases. Results: We introduce BioWarehouse, an open source toolkit for construc...
Thomas J. Lee, Yannick Pouliot, Valerie Wagner, Pr...