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» Shotgun Protein Sequencing
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BMCBI
2007
117views more  BMCBI 2007»
13 years 10 months ago
Supervised multivariate analysis of sequence groups to identify specificity determining residues
Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
Iain M. Wallace, Desmond G. Higgins
RECOMB
2012
Springer
12 years 12 days ago
Estimating the Accuracy of Multiple Alignments and its Use in Parameter Advising
We develop a novel and general approach to estimating the accuracy of protein multiple sequence alignments without knowledge of a reference alignment, and use our approach to addre...
Dan F. DeBlasio, Travis J. Wheeler, John D. Kececi...
BMCBI
2005
131views more  BMCBI 2005»
13 years 10 months ago
Functional annotation by identification of local surface similarities: a novel tool for structural genomics
Background: Protein function is often dependent on subsets of solvent-exposed residues that may exist in a similar three-dimensional configuration in non homologous proteins thus ...
Fabrizio Ferrè, Gabriele Ausiello, Andreas ...
EVOW
2006
Springer
14 years 1 months ago
Human Papillomavirus Risk Type Classification from Protein Sequences Using Support Vector Machines
Infection by the human papillomavirus (HPV) is associated with the development of cervical cancer. HPV can be classified to highand low-risk type according to its malignant potenti...
Sun Kim, Byoung-Tak Zhang
BMCBI
2008
138views more  BMCBI 2008»
13 years 10 months ago
Using neural networks and evolutionary information in decoy discrimination for protein tertiary structure prediction
Background: We present a novel method of protein fold decoy discrimination using machine learning, more specifically using neural networks. Here, decoy discrimination is represent...
Ching-Wai Tan, David T. Jones