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BMCBI
2007
120views more  BMCBI 2007»
13 years 10 months ago
Quantitative sequence-function relationships in proteins based on gene ontology
Background: The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs share function...
Vineet Sangar, Daniel J. Blankenberg, Naomi Altman...
ISMDA
2005
Springer
14 years 3 months ago
Extracting Molecular Diversity Between Populations Through Sequence Alignments
The use of sequence alignments for establishing protein homology relationships has an extensive tradition in the field of bioinformatics, and there is an increasing desire for more...
Steinar Thorvaldsen, Tor Flå, Nils Willassen
WABI
2009
Springer
142views Bioinformatics» more  WABI 2009»
14 years 4 months ago
Back-Translation for Discovering Distant Protein Homologies
Background: Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from ...
Marta Gîrdea, Laurent Noé, Gregory Ku...
BMCBI
2008
111views more  BMCBI 2008»
13 years 10 months ago
SciDBMaker: new software for computer-aided design of specialized biological databases
Background: The exponential growth of research in molecular biology has brought concomitant proliferation of databases for stocking its findings. A variety of protein sequence dat...
Riadh Hammami, Abdelmajid Zouhir, Karim Naghmouchi...
BMCBI
2010
136views more  BMCBI 2010»
13 years 10 months ago
SCPS: a fast implementation of a spectral method for detecting protein families on a genome-wide scale
Background: An important problem in genomics is the automatic inference of groups of homologous proteins from pairwise sequence similarities. Several approaches have been proposed...
Tamás Nepusz, Rajkumar Sasidharan, Alberto ...