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BMCBI
2008
175views more  BMCBI 2008»
13 years 7 months ago
Comprehensive inventory of protein complexes in the Protein Data Bank from consistent classification of interfaces
Background: Protein-protein interactions are ubiquitous and essential for all cellular processes. High-resolution X-ray crystallographic structures of protein complexes can reveal...
Andrew J. Bordner, Andrey A. Gorin
BMCBI
2010
151views more  BMCBI 2010»
13 years 7 months ago
Data reduction for spectral clustering to analyze high throughput flow cytometry data
Background: Recent biological discoveries have shown that clustering large datasets is essential for better understanding biology in many areas. Spectral clustering in particular ...
Habil Zare, Parisa Shooshtari, Arvind Gupta, Ryan ...
BMCBI
2007
166views more  BMCBI 2007»
13 years 7 months ago
Optimization of filtering criterion for SEQUEST database searching to improve proteome coverage in shotgun proteomics
Background: In proteomic analysis, MS/MS spectra acquired by mass spectrometer are assigned to peptides by database searching algorithms such as SEQUEST. The assignations of pepti...
Xinning Jiang, Xiaogang Jiang, Guanghui Han, Mingl...
BMCBI
2007
129views more  BMCBI 2007»
13 years 7 months ago
Algebraic correction methods for computational assessment of clone overlaps in DNA fingerprint mapping
Background: The Sulston score is a well-established, though approximate metric for probabilistically evaluating postulated clone overlaps in DNA fingerprint mapping. It is known t...
Michael C. Wendl
BMCBI
2007
107views more  BMCBI 2007»
13 years 7 months ago
A general and efficient method for estimating continuous IBD functions for use in genome scans for QTL
Background: Identity by descent (IBD) matrix estimation is a central component in mapping of Quantitative Trait Loci (QTL) using variance component models. A large number of algor...
Francois Besnier, Örjan Carlborg