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» Simulating the Hallmarks of Cancer
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BMCBI
2007
140views more  BMCBI 2007»
13 years 8 months ago
Prediction potential of candidate biomarker sets identified and validated on gene expression data from multiple datasets
Background: Independently derived expression profiles of the same biological condition often have few genes in common. In this study, we created populations of expression profiles...
Michael Gormley, William Dampier, Adam Ertel, Bilg...
BMCBI
2006
178views more  BMCBI 2006»
13 years 8 months ago
Correlation analysis of two-dimensional gel electrophoretic protein patterns and biological variables
Background: Two-dimensional gel electrophoresis (2DE) is a powerful technique to examine post-translational modifications of complexly modulated proteins. Currently, spot detectio...
Werner W. V. B. Van Belle, Nina N. A. Anensen, Ing...
BMCBI
2007
148views more  BMCBI 2007»
13 years 8 months ago
Computation of significance scores of unweighted Gene Set Enrichment Analyses
Background: Gene Set Enrichment Analysis (GSEA) is a computational method for the statistical evaluation of sorted lists of genes or proteins. Originally GSEA was developed for in...
Andreas Keller, Christina Backes, Hans-Peter Lenho...
BMCBI
2011
13 years 3 months ago
Motif-guided sparse decomposition of gene expression data for regulatory module identification
Background: Genes work coordinately as gene modules or gene networks. Various computational approaches have been proposed to find gene modules based on gene expression data; for e...
Ting Gong, Jianhua Xuan, Li Chen, Rebecca B. Riggi...
BMCBI
2011
13 years 5 days ago
A fast and accurate method to detect allelic genomic imbalances underlying mosaic rearrangements using SNP array data
Background: Mosaicism for copy number and copy neutral chromosomal rearrangements has been recently identified as a relatively common source of genetic variation in the normal pop...
Juan R. González, Benjamin Rodriguez-Santia...