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BMCBI
2011
12 years 10 months ago
To aggregate or not to aggregate high-dimensional classifiers
Background: High-throughput functional genomics technologies generate large amount of data with hundreds or thousands of measurements per sample. The number of sample is usually m...
Cheng-Jian Xu, Huub C. J. Hoefsloot, Age K. Smilde
BMCBI
2011
12 years 10 months ago
Elastic SCAD as a novel penalization method for SVM classification tasks in high-dimensional data
Background: Classification and variable selection play an important role in knowledge discovery in highdimensional data. Although Support Vector Machine (SVM) algorithms are among...
Natalia Becker, Grischa Toedt, Peter Lichter, Axel...
BMCBI
2011
12 years 10 months ago
Inference of Chromosome-Specific Copy Numbers Using Population Haplotypes
Background: Using microarray and sequencing platforms, a large number of copy number variations (CNVs) have been identified in humans. In practice, because our human genome is a d...
Yao-Ting Huang, Min-Han Wu
BMCBI
2011
12 years 10 months ago
A Simple Approach to Ranking Differentially Expressed Gene Expression Time Courses through Gaussian Process Regression
Background: The analysis of gene expression from time series underpins many biological studies. Two basic forms of analysis recur for data of this type: removing inactive (quiet) ...
Alfredo A. Kalaitzis, Neil D. Lawrence
BMCBI
2011
12 years 10 months ago
Proportion statistics to detect differentially expressed genes: a comparison with log-ratio statistics
Background: In genetic transcription research, gene expression is typically reported in a test sample relative to a reference sample. Laboratory assays that measure gene expressio...
Tracy L. Bergemann, Jason Wilson
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