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» Smoothing Gene Expression Using Biological Networks
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BMCBI
2005
152views more  BMCBI 2005»
13 years 7 months ago
GeneKeyDB: A lightweight, gene-centric, relational database to support data mining environments
Background: The analysis of biological data is greatly enhanced by existing or emerging databases. Most existing databases, with few exceptions are not designed to easily support ...
S. A. Kirov, X. Peng, E. Baker, D. Schmoyer, B. Zh...
SAC
2008
ACM
13 years 7 months ago
Bayesian inference for a discretely observed stochastic kinetic model
The ability to infer parameters of gene regulatory networks is emerging as a key problem in systems biology. The biochemical data are intrinsically stochastic and tend to be observ...
Richard J. Boys, Darren J. Wilkinson, Thomas B. L....
CSB
2003
IEEE
130views Bioinformatics» more  CSB 2003»
14 years 29 days ago
A Computational Approach to Reconstructing Gene Regulatory Networks
Reverse-engineering of gene networks using linear models often results in an underdetermined system because of excessive unknown parameters. In addition, the practical utility of ...
Xutao Deng, Hesham H. Ali
BMCBI
2007
103views more  BMCBI 2007»
13 years 7 months ago
eQTL Viewer: visualizing how sequence variation affects genome-wide transcription
Background: Expression Quantitative Trait Locus (eQTL) mapping methods have been used to identify the genetic basis of gene expression variations. To map eQTL, thousands of expres...
Wei Zou, David L. Aylor, Zhao-Bang Zeng
ISBRA
2007
Springer
14 years 1 months ago
Discovering Relations Among GO-Annotated Clusters by Graph Kernel Methods
The biological interpretation of large-scale gene expression data is one of the challenges in current bioinformatics. The state-of-theart approach is to perform clustering and then...
Italo Zoppis, Daniele Merico, Marco Antoniotti, Bu...