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» Smoothing Gene Expression Using Biological Networks
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BMCBI
2008
77views more  BMCBI 2008»
13 years 9 months ago
A simple and robust method for connecting small-molecule drugs using gene-expression signatures
Background: Interaction of a drug or chemical with a biological system can result in a geneexpression profile or signature characteristic of the event. Using a suitably robust alg...
Shu-Dong Zhang, Timothy W. Gant
BMCBI
2007
78views more  BMCBI 2007»
13 years 9 months ago
Improved human disease candidate gene prioritization using mouse phenotype
Background: The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors. High-thro...
Jing Chen, Huan Xu, Bruce J. Aronow, Anil G. Jegga
NAR
2006
142views more  NAR 2006»
13 years 9 months ago
miRNAMap: genomic maps of microRNA genes and their target genes in mammalian genomes
Recent work has demonstrated that microRNAs (miRNAs) are involved in critical biological processes by suppressing the translation of coding genes. This work develops an integrated...
Paul Wei-Che Hsu, Hsien-Da Huang, Sheng-Da Hsu, Li...
RECOMB
2008
Springer
14 years 9 months ago
Integrating Sequence and Topology for Efficient and Accurate Detection of Horizontal Gene Transfer
Abstract. One phylogeny-based approach to horizontal gene transfer (HGT) detection entails comparing the topology of a gene tree to that of the species tree, and using their differ...
Cuong Than, Guohua Jin, Luay Nakhleh
BIOCOMP
2009
13 years 10 months ago
Inferring Gene Regulatory Networks from Asynchronous Microarray Data
Modern approaches to treating genetic disorders, cancers and even epidemics rely on a detailed understanding of the underlying gene signaling network. Previous work has used time s...
David Oviatt, Mark J. Clement, Quinn Snell, Kennet...