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» Somatic evolution of cancer
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BMCBI
2010
113views more  BMCBI 2010»
13 years 7 months ago
A classification model for distinguishing copy number variants from cancer-related alterations
Background: Both somatic copy number alterations (CNAs) and germline copy number variants (CNVs) that are prevalent in healthy individuals can appear as recurrent changes in compa...
Irina Ostrovnaya, Gouri Nanjangud, Adam B. Olshen
BMCBI
2010
106views more  BMCBI 2010»
13 years 7 months ago
TumorBoost: Normalization of allele-specific tumor copy numbers from a single pair of tumor-normal genotyping microarrays
Background: High-throughput genotyping microarrays assess both total DNA copy number and allelic composition, which makes them a tool of choice for copy number studies in cancer, ...
Henrik Bengtsson, Pierre Neuvial, Terence P. Speed
BMCBI
2008
115views more  BMCBI 2008»
13 years 7 months ago
Probe signal correction for differential methylation hybridization experiments
Background: Non-biological signal (or noise) has been the bane of microarray analysis. Hybridization effects related to probe-sequence composition and DNA dye-probe interactions h...
Dustin P. Potter, Pearlly Yan, Tim Hui-Ming Huang,...
ISBI
2006
IEEE
14 years 8 months ago
Cancer disease: integrative modelling approaches
Cancer is a complex disease in which a variety of phenomena interact over a wide range of spatial and temporal scales. In this article a theoretical framework will be introduced t...
Helen M. Byrne, Markus R. Owen, Tomas Alarcó...
ISBI
2006
IEEE
14 years 8 months ago
Automatic landmark detection in uterine cervix images for indexing in a content-retrieval system
This work is motivated by the need for visual information extraction and management in the growing field of content based image retrieval from medical archives. In particular it f...
Gali Zimmerman, Shiri Gordon, Hayit Greenspan