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    BMCBI
    2007
    117views more  BMCBI 2007»
    Supervised multivariate analysis of sequence groups to identify specificity determining residues
    13 years 9 months ago
    Supervised multivariate analysis of sequence groups to identify specificity determining residues
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    Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
    Iain M. Wallace, Desmond G. Higgins
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    BMCBI
    2007
    95views more  BMCBI 2007»
    ZPS: visualization of recent adaptive evolution of proteins
    13 years 9 months ago
    ZPS: visualization of recent adaptive evolution of proteins
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    Background: Detection of adaptive amino acid changes in proteins under recent short-term selection is of great interest for researchers studying microevolutionary processes in mic...
    Sujay Chattopadhyay, Daniel E. Dykhuizen, Evgeni V...
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    BMCBI
    2008
    118views more  BMCBI 2008»
    PseudoGeneQuest - Service for identification of different pseudogene types in the human genome
    13 years 9 months ago
    PseudoGeneQuest - Service for identification of different pseudogene types in the human genome
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    Background: Pseudogenes, nonfunctional copies of genes, evolve fast due the lack of evolutionary pressures and thus appear in several different forms. PseudoGeneQuest is an online...
    Csaba P. Ortutay, Mauno Vihinen
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    BMCBI
    2007
    86views more  BMCBI 2007»
    Toxicogenomic analysis incorporating operon-transcriptional coupling and toxicant concentration-expression response: analysis of
    13 years 9 months ago
    Toxicogenomic analysis incorporating operon-transcriptional coupling and toxicant concentration-expression response: analysis of
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    Background: Deficiencies in microarray technology cause unwanted variation in the hybridization signal, obscuring the true measurements of intracellular transcript levels. Here we...
    William O. Ward, Carol D. Swartz, Steffen Porwolli...
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    BMCBI
    2010
    87views more  BMCBI 2010»
    Epigenetic domains found in mouse embryonic stem cells via a hidden Markov model
    13 years 9 months ago
    Epigenetic domains found in mouse embryonic stem cells via a hidden Markov model
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    Background: Epigenetics is an important layer of transcriptional control necessary for cell-type specific gene regulation. Recent studies have shown significant epigenetic pattern...
    Jessica L. Larson, Guo-Cheng Yuan
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