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BMCBI
2006
183views more  BMCBI 2006»
13 years 9 months ago
Mining gene expression data by interpreting principal components
Background: There are many methods for analyzing microarray data that group together genes having similar patterns of expression over all conditions tested. However, in many insta...
Joseph C. Roden, Brandon W. King, Diane Trout, Ali...
BMCBI
2006
95views more  BMCBI 2006»
13 years 9 months ago
Estimate haplotype frequencies in pedigrees
Background: Haplotype analysis has gained increasing attention in the context of association studies of disease genes and drug responsivities over the last years. The potential us...
Qiangfeng Zhang, YuZhong Zhao, Guoliang Chen, Yun ...
BMCBI
2006
103views more  BMCBI 2006»
13 years 9 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...
BMCBI
2007
122views more  BMCBI 2007»
13 years 9 months ago
Dissecting complex transcriptional responses using pathway-level scores based on prior information
Background: The genomewide pattern of changes in mRNA expression measured using DNA microarrays is typically a complex superposition of the response of multiple regulatory pathway...
Harmen J. Bussemaker, Lucas D. Ward, André ...
ENVSOFT
2007
108views more  ENVSOFT 2007»
13 years 9 months ago
Modeling biocomplexity - actors, landscapes and alternative futures
: Increasingly, models (and modelers) are being asked to address the interactions between human influences, ecological processes, and landscape dynamics that impact many diverse as...
John P. Bolte, David W. Hulse, Stanley V. Gregory,...