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» Statistical analysis of domains in interacting protein pairs
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RECOMB
2008
Springer
14 years 9 months ago
Detecting Disease-Specific Dysregulated Pathways Via Analysis of Clinical Expression Profiles
We present a method for identifying connected gene subnetworks significantly enriched for genes that are dysregulated in specimens of a disease. These subnetworks provide a signat...
Igor Ulitsky, Richard M. Karp, Ron Shamir
HICSS
2010
IEEE
237views Biometrics» more  HICSS 2010»
14 years 3 months ago
Data Aggregation and Analysis for Cancer Statistics - A Visual Analytics Approach
The disparity between data collected in rural and urban counties is often detrimental in the appropriate analysis of cancer care statistics. Low counts drastically affect the inci...
Ross Maciejewski, Travis Drake, Stephen Rudolph, A...
BMCBI
2010
109views more  BMCBI 2010»
13 years 9 months ago
Functional characterization and topological modularity of molecular interaction networks
Background: Analyzing interaction networks for functional characterization poses significant challenges arising from the noisy, incomplete, and generic nature of both the interact...
Jayesh Pandey, Mehmet Koyutürk, Ananth Grama
BMCBI
2004
177views more  BMCBI 2004»
13 years 8 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
NAR
2011
235views Computer Vision» more  NAR 2011»
12 years 12 months ago
P2CS: a database of prokaryotic two-component systems
P2CS (http://www.p2cs.org) is a specialized database for prokaryotic two-component systems (TCSs), virtually ubiquitous signalling proteins which regulate a wide range of physiolo...
Mohamed Barakat, Philippe Ortet, David E. Whitwort...