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BMCBI
2010
133views more  BMCBI 2010»
13 years 7 months ago
Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...
Limin Li, Xiaobo Zhou, Wai-Ki Ching, Ping Wang
BMCBI
2007
102views more  BMCBI 2007»
13 years 7 months ago
Multivariate Analysis and Visualization of Splicing Correlations in Single-Gene Transcriptomes
Background: RNA metabolism, through 'combinatorial splicing', can generate enormous structural diversity in the proteome. Alternative domains may interact, however, with...
Mark C. Emerick, Giovanni Parmigiani, William S. A...
BMCBI
2008
146views more  BMCBI 2008»
13 years 7 months ago
Rank-based edge reconstruction for scale-free genetic regulatory networks
Background: The reconstruction of genetic regulatory networks from microarray gene expression data has been a challenging task in bioinformatics. Various approaches to this proble...
Guanrao Chen, Peter Larsen, Eyad Almasri, Yang Dai
CCR
2008
118views more  CCR 2008»
13 years 7 months ago
A generic language for application-specific flow sampling
Flow records gathered by routers provide valuable coarse-granularity traffic information for several measurement-related network applications. However, due to high volumes of traf...
Harsha V. Madhyastha, Balachander Krishnamurthy
CORR
2010
Springer
114views Education» more  CORR 2010»
13 years 7 months ago
Settling the Polynomial Learnability of Mixtures of Gaussians
Given data drawn from a mixture of multivariate Gaussians, a basic problem is to accurately estimate the mixture parameters. We give an algorithm for this problem that has running ...
Ankur Moitra, Gregory Valiant
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