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BIOINFORMATICS
2008
97views more  BIOINFORMATICS 2008»
13 years 6 months ago
An integrated system for studying residue coevolution in proteins
Residue coevolution has recently emerged as an important concept, especially in the context of protein structures. While a multitude of different functions for quantifying it have...
Kevin Y. Yip, Prianka Patel, Philip M. Kim, Donald...
BMCBI
2010
156views more  BMCBI 2010»
13 years 6 months ago
Global screening of potential Candida albicans biofilm-related transcription factors via network comparison
Background: Candida albicans is a commonly encountered fungal pathogen in humans. The formation of biofilm is a major virulence factor in C. albicans pathogenesis and is related t...
Yu-Chao Wang, Chung-Yu Lan, Wen-Ping Hsieh, Luis A...
BMCBI
2010
116views more  BMCBI 2010»
13 years 6 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
BMCBI
2007
138views more  BMCBI 2007»
13 years 6 months ago
A full Bayesian hierarchical mixture model for the variance of gene differential expression
Background: In many laboratory-based high throughput microarray experiments, there are very few replicates of gene expression levels. Thus, estimates of gene variances are inaccur...
Samuel O. M. Manda, Rebecca E. Walls, Mark S. Gilt...
CBRMD
2008
167views more  CBRMD 2008»
13 years 6 months ago
Case-based Reasoning for Diagnosis of Stress using Enhanced Cosine and Fuzzy Similarity
Intelligent analysis of heterogeneous data and information sources for efficient decision support presents an interesting yet challenging task in clinical environments. This is par...
Mobyen Uddin Ahmed, Shahina Begum, Peter Funk, Nin...