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» Structural Protein Interactions: From Months to Minutes
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BMCBI
2004
177views more  BMCBI 2004»
13 years 8 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
BIBM
2010
IEEE
158views Bioinformatics» more  BIBM 2010»
13 years 6 months ago
Protein-protein interaction prediction via Collective Matrix Factorization
Abstract--Protein-protein interactions (PPI) play an important role in cellular processes and metabolic processes within a cell. An important task is to determine the existence of ...
Qian Xu, Evan Wei Xiang, Qiang Yang
VIS
2009
IEEE
238views Visualization» more  VIS 2009»
14 years 9 months ago
An Interactive Visualization Tool for Multi-channel Confocal Microscopy Data in Neurobiology Research
Confocal microscopy is widely used in neurobiology for studying the three-dimensional structure of the nervous system. Confocal image data are often multi-channel, with each channe...
Yong Wan, Hideo Otsuna, Chi-Bin Chien, Charles ...
BMCBI
2006
94views more  BMCBI 2006»
13 years 8 months ago
Novel knowledge-based mean force potential at the profile level
Background: The development and testing of functions for the modeling of protein energetics is an important part of current research aimed at understanding protein structure and f...
Qiwen Dong, Xiaolong Wang, Lei Lin
BIOWIRE
2007
Springer
14 years 2 months ago
Evolutionary and Temporal Dynamics of Transcriptional Regulatory Networks
Transcriptional regulation is a key mechanism that allows cells to make the appropriate amount of proteins at the right time. This is mediated by transcription factors that respond...
M. Madan Babu