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BMCBI
2011
13 years 5 days ago
Cell Subset Prediction for Blood Genomic Studies
Background: Genome-wide transcriptional profiling of patient blood samples offers a powerful tool to investigate underlying disease mechanisms and personalized treatment decisions...
Christopher R. Bolen, Mohamed Uduman, Steven H. Kl...
BMCBI
2008
96views more  BMCBI 2008»
13 years 8 months ago
Use of normalization methods for analysis of microarrays containing a high degree of gene effects
Background: High-throughput microarrays are widely used to study gene expression across tissues and developmental stages. Analysis of gene expression data is challenging in these ...
Terri T. Ni, William J. Lemon, Yu Shyr, Tao P. Zho...
BMCBI
2006
123views more  BMCBI 2006»
13 years 8 months ago
Characterizing disease states from topological properties of transcriptional regulatory networks
Background: High throughput gene expression experiments yield large amounts of data that can augment our understanding of disease processes, in addition to classifying samples. He...
David Tuck, Harriet Kluger, Yuval Kluger
BMCBI
2007
227views more  BMCBI 2007»
13 years 8 months ago
Growing functional modules from a seed protein via integration of protein interaction and gene expression data
Background: Nowadays modern biology aims at unravelling the strands of complex biological structures such as the protein-protein interaction (PPI) networks. A key concept in the o...
Ioannis A. Maraziotis, Konstantina Dimitrakopoulou...
BIBE
2004
IEEE
179views Bioinformatics» more  BIBE 2004»
14 years 10 days ago
Incorporating Ontology-Driven Similarity Knowledge into Functional Genomics: An Exploratory Study
This research explores the feasibility of semantic similarity approaches to supporting predictive tasks in functional genomics. It aims to establish potential relationships betwee...
Francisco Azuaje, Olivier Bodenreider