The PUMA2 system (available at http://compbio.mcs. 10 anl.gov/puma2) is an interactive, integrated bioinformatics environment for high-throughput genetic sequence analysis and met...
Natalia Maltsev, Elizabeth M. Glass, Dinanath Sula...
Background: In the analysis of networks we frequently require the statistical significance of some network statistic, such as measures of similarity for the properties of interact...
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
Background: Probabilistic models for sequence comparison (such as hidden Markov models and pair hidden Markov models for proteins and mRNAs, or their context-free grammar counterp...
Background: Existing hidden Markov model decoding algorithms do not focus on approximately identifying the sequence feature boundaries. Results: We give a set of algorithms to com...