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    BMCBI
    2010
    99views more  BMCBI 2010»
    A statistical method for excluding non-variable CpG sites in high-throughput DNA methylation profiling
    13 years 8 months ago
    A statistical method for excluding non-variable CpG sites in high-throughput DNA methylation profiling
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    Background: High-throughput DNA methylation arrays are likely to accelerate the pace of methylation biomarker discovery for a wide variety of diseases. A potential problem with a ...
    Hailong Meng, Andrew R. Joyce, Daniel E. Adkins, P...
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    BMCBI
    2010
    99views more  BMCBI 2010»
    Prediction of novel precursor miRNAs using a context-sensitive hidden Markov model (CSHMM)
    13 years 8 months ago
    Prediction of novel precursor miRNAs using a context-sensitive hidden Markov model (CSHMM)
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    Background: It has been apparent in the last few years that small non coding RNAs (ncRNA) play a very significant role in biological regulation. Among these microRNAs (miRNAs), 22...
    Sumeet Agarwal, Candida Vaz, Alok Bhattacharya, As...
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    BMCBI
    2007
    200views more  BMCBI 2007»
    Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data
    13 years 8 months ago
    Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data
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    Background: Genomic deletions and duplications are important in the pathogenesis of diseases, such as cancer and mental retardation, and have recently been shown to occur frequent...
    Ágnes Baross, Allen D. Delaney, H. Irene Li...
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    BMCBI
    2007
    97views more  BMCBI 2007»
    A verification protocol for the probe sequences of Affymetrix genome arrays reveals high probe accuracy for studies in mouse, hu
    13 years 8 months ago
    A verification protocol for the probe sequences of Affymetrix genome arrays reveals high probe accuracy for studies in mouse, hu
    Download  gbb.eldoc.ub.rug.nl
    Background: The Affymetrix GeneChip technology uses multiple probes per gene to measure its expression level. Individual probe signals can vary widely, which hampers proper interp...
    Rudi Alberts, Peter Terpstra, Menno Hardonk, Leoni...
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    BMCBI
    2008
    139views more  BMCBI 2008»
    A topological transformation in evolutionary tree search methods based on maximum likelihood combining p-ECR and neighbor joinin
    13 years 8 months ago
    A topological transformation in evolutionary tree search methods based on maximum likelihood combining p-ECR and neighbor joinin
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    Background: Inference of evolutionary trees using the maximum likelihood principle is NP-hard. Therefore, all practical methods rely on heuristics. The topological transformations...
    Maozu Guo, Jian-Fu Li, Yang Liu
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