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» The Equivalence between Biology and Computation
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BMCBI
2007
128views more  BMCBI 2007»
13 years 9 months ago
A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand bindin
Background: An accurate description of protein shape derived from protein structure is necessary to establish an understanding of protein-ligand interactions, which in turn will l...
Lei Xie, Philip E. Bourne
ALIFE
2005
13 years 9 months ago
Material Representations: From the Genetic Code to the Evolution of Cellular Automata
We present a new definition of the concept of representation for cognitive science that is based on a study of the origin of structures that are used to store memory in evolving sy...
Luis Mateus Rocha, Wim Hordijk
BMCBI
2005
104views more  BMCBI 2005»
13 years 9 months ago
Scoring functions for transcription factor binding site prediction
Background: Transcription factor binding site (TFBS) prediction is a difficult problem, which requires a good scoring function to discriminate between real binding sites and backg...
Markus T. Friberg, Peter von Rohr, Gaston H. Gonne...
BMCBI
2004
135views more  BMCBI 2004»
13 years 9 months ago
Determination of the differentially expressed genes in microarray experiments using local FDR
Background: Thousands of genes in a genomewide data set are tested against some null hypothesis, for detecting differentially expressed genes in microarray experiments. The expect...
Julie Aubert, Avner Bar-Hen, Jean-Jacques Daudin, ...
BMCBI
2004
136views more  BMCBI 2004»
13 years 9 months ago
A SNP-centric database for the investigation of the human genome
Background: Single Nucleotide Polymorphisms (SNPs) are an increasingly important tool for genetic and biomedical research. Although current genomic databases contain information o...
Alberto Riva, Isaac S. Kohane