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» The Generalized FITC Approximation
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BMCBI
2010
109views more  BMCBI 2010»
13 years 10 months ago
Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model
Background: The binding of peptide fragments of extracellular peptides to class II MHC is a crucial event in the adaptive immune response. Each MHC allotype generally binds a dist...
Andrew J. Bordner, Hans D. Mittelmann
BMCBI
2010
113views more  BMCBI 2010»
13 years 10 months ago
Statistical method on nonrandom clustering with application to somatic mutations in cancer
Background: Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells. As a conse...
Jingjing Ye, Adam Pavlícek, Elizabeth A. Lu...
BMCBI
2007
173views more  BMCBI 2007»
13 years 10 months ago
Predicting state transitions in the transcriptome and metabolome using a linear dynamical system model
Background: Modelling of time series data should not be an approximation of input data profiles, but rather be able to detect and evaluate dynamical changes in the time series dat...
Ryoko Morioka, Shigehiko Kanaya, Masami Y. Hirai, ...
BMCBI
2008
139views more  BMCBI 2008»
13 years 10 months ago
Hierarchical structure of cascade of primary and secondary periodicities in Fourier power spectrum of alphoid higher order repea
Background: Identification of approximate tandem repeats is an important task of broad significance and still remains a challenging problem of computational genomics. Often there ...
Vladimir Paar, Nenad Pavin, Ivan Basar, Marija Ros...
BMCBI
2008
171views more  BMCBI 2008»
13 years 10 months ago
Comparative analysis of five protein-protein interaction corpora
Background: Growing interest in the application of natural language processing methods to biomedical text has led to an increasing number of corpora and methods targeting protein-...
Sampo Pyysalo, Antti Airola, Juho Heimonen, Jari B...