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BIOCOMP
2006
14 years 17 days ago
The Generalized Topological Overlap Matrix for Detecting Modules in Gene Networks
Systems biologic studies of gene and protein interaction networks have found that these networks are comprised of `modules' (groups of tightly interconnected nodes). Module i...
Andy M. Yip, Steve Horvath
BIOCOMP
2006
14 years 17 days ago
The Multi-Node Topological Overlap Measure For Gene Neighborhood Analysis
Defining the neighborhood of an initial set of nodes is an important task in network analysis. For example, we show that the neighborhood of an initial set of brain cancer related ...
Ai Li, Steve Horvath
BMCBI
2007
157views more  BMCBI 2007»
13 years 11 months ago
Constructing gene co-expression networks and predicting functions of unknown genes by random matrix theory
Background: Large-scale sequencing of entire genomes has ushered in a new age in biology. One of the next grand challenges is to dissect the cellular networks consisting of many i...
Feng Luo, Yunfeng Yang, Jianxin Zhong, Haichun Gao...
BMCBI
2007
111views more  BMCBI 2007»
13 years 11 months ago
Modular co-evolution of metabolic networks
Background: The architecture of biological networks has been reported to exhibit high level of modularity, and to some extent, topological modules of networks overlap with known f...
Jing Zhao, Guohui Ding, Lin Tao, Hong Yu, Zhong-Ha...
BMCBI
2011
13 years 2 months ago
MINE: Module Identification in NEtworks
Background: Graphical models of network associations are useful for both visualizing and integrating multiple types of association data. Identifying modules, or groups of function...
Kahn Rhrissorrakrai, Kristin C. Gunsalus