500 search results - page 60 / 100 » The PIR-International Protein Sequence Database |
BMCBI
2008
13 years 7 months ago
2008
Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...
BICOB
2009
Springer
14 years 6 days ago
2009
Springer
Protein phosphorylation is a crucial regulatory mechanism in various organisms. With recent improvements in mass spectrometry, phosphorylation site data are rapidly accumulating. D...
BMCBI
2010
13 years 7 months ago
2010
Background: Profile hidden Markov models (profile-HMMs) are sensitive tools for remote protein homology detection, but the main scoring algorithms, Viterbi or Forward, require con...
BMCBI
2007
13 years 7 months ago
2007
Background: In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epito...
BMCBI
2006
13 years 7 months ago
2006
Background: Many vital biological processes, including transcription and splicing, require a combination of short, degenerate sequence patterns, or motifs, adjacent to defined seq...