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» The Pfam protein families database
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NAR
2008
103views more  NAR 2008»
13 years 7 months ago
DBD--taxonomically broad transcription factor predictions: new content and functionality
DNA-binding domain (DBD) is a database of predicted sequence-specific DNA-binding transcription factors (TFs) for all publicly available proteomes. The proteomes have increased fr...
Derek Wilson, Varodom Charoensawan, Sarah K. Kumme...
BMCBI
2008
130views more  BMCBI 2008»
13 years 7 months ago
A novel series of compositionally biased substitution matrices for comparing Plasmodium proteins
Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...
Kevin Brick, Elisabetta Pizzi
BMCBI
2008
145views more  BMCBI 2008»
13 years 7 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
NAR
2011
188views Computer Vision» more  NAR 2011»
12 years 10 months ago
ThYme: a database for thioester-active enzymes
The ThYme (Thioester-active enzYme; http://www .enzyme.cbirc.iastate.edu) database has been constructed to bring together amino acid sequences and 3D (tertiary) structures of all ...
David C. Cantu, Yingfei Chen, Matthew L. Lemons, P...
JCB
2002
116views more  JCB 2002»
13 years 7 months ago
A Novel Approach to Remote Homology Detection: Jumping Alignments
We describe a new algorithm for protein classi cation and the detection of remote homologs. The rationale is to exploit both vertical and horizontal information of a multiple alig...
Rainer Spang, Marc Rehmsmeier, Jens Stoye