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BMCBI
2010
117views more  BMCBI 2010»
13 years 8 months ago
Extracting causal relations on HIV drug resistance from literature
Background: In HIV treatment it is critical to have up-to-date resistance data of applicable drugs since HIV has a very high rate of mutation. These data are made available throug...
Quoc-Chinh Bui, Breanndán Ó Nuall&aa...
BMCBI
2010
104views more  BMCBI 2010»
13 years 8 months ago
A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-or
Background: G protein-coupled receptors (GPCRs) represent a family of well-characterized drug targets with significant therapeutic value. Phylogenetic classifications may help to ...
Eelke van der Horst, Julio E. Peironcely, Adriaan ...
BMCBI
2010
140views more  BMCBI 2010»
13 years 8 months ago
Quantification and deconvolution of asymmetric LC-MS peaks using the bi-Gaussian mixture model and statistical model selection
Background: Liquid chromatography-mass spectrometry (LC-MS) is one of the major techniques for the quantification of metabolites in complex biological samples. Peak modeling is on...
Tianwei Yu, Hesen Peng
BMCBI
2010
113views more  BMCBI 2010»
13 years 8 months ago
Class prediction for high-dimensional class-imbalanced data
Background: The goal of class prediction studies is to develop rules to accurately predict the class membership of new samples. The rules are derived using the values of the varia...
Rok Blagus, Lara Lusa
BMCBI
2007
62views more  BMCBI 2007»
13 years 8 months ago
Missing channels in two-colour microarray experiments: Combining single-channel and two-channel data
Background: There are mechanisms, notably ozone degradation, that can damage a single channel of two-channel microarray experiments. Resulting analyses therefore often choose betw...
Andy G. Lynch, David E. Neal, John D. Kelly, Glyn ...