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BMCBI
2005
201views more  BMCBI 2005»
13 years 11 months ago
Principal component analysis for predicting transcription-factor binding motifs from array-derived data
Background: The responses to interleukin 1 (IL-1) in human chondrocytes constitute a complex regulatory mechanism, where multiple transcription factors interact combinatorially to...
Yunlong Liu, Matthew P. Vincenti, Hiroki Yokota
TEC
2008
99views more  TEC 2008»
13 years 11 months ago
A Drug Candidate Design Environment Using Evolutionary Computation
Abstract-- This article describes the Candidate Design Environment we developed for efficient identification of promising drug candidates. Developing effective drugs from active mo...
M. Ihsan Ecemis, J. Wikel, C. Bingham, Eric Bonabe...
GECCO
2004
Springer
212views Optimization» more  GECCO 2004»
14 years 4 months ago
An Evolutionary Autonomous Agent with Visual Cortex and Recurrent Spiking Columnar Neural Network
Spiking neural networks are computationally more powerful than conventional artificial neural networks. Although this fact should make them especially desirable for use in evoluti...
Rich Drewes, James B. Maciokas, Sushil J. Louis, P...
IJSYSC
2000
74views more  IJSYSC 2000»
13 years 11 months ago
Towards the evolutionary emergence of increasingly complex advantageous behaviours
The generation of complex entities with advantageous behaviours beyond our manual design capability requires long-term incremental evolution with continuing emergence. In this pap...
A. D. Channon, Robert I. Damper
KDD
2009
ACM
178views Data Mining» more  KDD 2009»
14 years 11 months ago
Constrained optimization for validation-guided conditional random field learning
Conditional random fields(CRFs) are a class of undirected graphical models which have been widely used for classifying and labeling sequence data. The training of CRFs is typicall...
Minmin Chen, Yixin Chen, Michael R. Brent, Aaron E...