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» The challenges of automated methods for integrating systems
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BMCBI
2010
150views more  BMCBI 2010»
13 years 8 months ago
Systematic calibration of a cell signaling network model
Background: Mathematical modeling is being applied to increasingly complex biological systems and datasets; however, the process of analyzing and calibrating against experimental ...
Kyoung Ae Kim, Sabrina L. Spencer, John G. Albeck,...
GIS
2004
ACM
14 years 9 months ago
A novel improvement to the R*-tree spatial index using gain/loss metrics
The R*-tree is a state-of-the-art spatial index structure. It has already found its way into commercial systems. The most important improvement of the R*-tree over the original R-...
Donghui Zhang, Tian Xia
BMCBI
2010
138views more  BMCBI 2010»
13 years 8 months ago
A database and API for variation, dense genotyping and resequencing data
Background: Advances in sequencing and genotyping technologies are leading to the widespread availability of multi-species variation data, dense genotype data and large-scale rese...
Daniel Rios, William M. McLaren, Yuan Chen, Ewan B...
ICSE
2003
IEEE-ACM
14 years 8 months ago
Patterns, Frameworks, and Middleware: Their Synergistic Relationships
The knowledge required to develop complex software has historically existed in programming folklore, the heads of experienced developers, or buried deep in the code. These locatio...
Douglas C. Schmidt, Frank Buschmann
BMCBI
2007
169views more  BMCBI 2007»
13 years 8 months ago
Transcriptional regulatory network refinement and quantification through kinetic modeling, gene expression microarray data and i
Background: Gene expression microarray and other multiplex data hold promise for addressing the challenges of cellular complexity, refined diagnoses and the discovery of well-targ...
Abdallah Sayyed-Ahmad, Kagan Tuncay, Peter J. Orto...