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» The evolutionary capacity of protein structures
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CEC
2010
IEEE
13 years 8 months ago
A parallel framework for multi-objective evolutionary optimization
This work focuses on the development of a parallel framework method to improve the effectiveness and the efficiency of the obtained solutions by Multi-objective Evolutionary Algori...
Dipankar Dasgupta, David Camilo Becerra Romero, Al...
BIOWIRE
2007
Springer
14 years 1 months ago
Evolutionary and Temporal Dynamics of Transcriptional Regulatory Networks
Transcriptional regulation is a key mechanism that allows cells to make the appropriate amount of proteins at the right time. This is mediated by transcription factors that respond...
M. Madan Babu
GECCO
2000
Springer
127views Optimization» more  GECCO 2000»
13 years 11 months ago
Evolving Molecules for Drug Design Using Genetic Algorithms via Molecular Trees
We present a new representation for a genetic algorithm to evolve molecular structures representing possible drugs that bind to a given protein target receptor. Our representation...
Gerard Kian-Meng Goh, James A. Foster
BMCBI
2010
83views more  BMCBI 2010»
13 years 7 months ago
Trees on networks: resolving statistical patterns of phylogenetic similarities among interacting proteins
Background: Phylogenies capture the evolutionary ancestry linking extant species. Correlations and similarities among a set of species are mediated by and need to be understood in...
William P. Kelly, Michael P. H. Stumpf
BMCBI
2007
126views more  BMCBI 2007»
13 years 7 months ago
High-throughput identification of interacting protein-protein binding sites
Background: With the advent of increasing sequence and structural data, a number of methods have been proposed to locate putative protein binding sites from protein surfaces. Ther...
Jo-Lan Chung, Wei Wang, Philip E. Bourne