Aligning multiple DNA or protein sequences is a fundamental step in the analyses of phylogeny, homology and molecular structure. Heuristic algorithms are applied because optimal mu...
This paper1 introduces a simple model for evolutionary dynamics approaching the “coding threshold”, where the capacity to symbolically represent nucleic acid sequences emerges ...
Piraveenan Mahendra, Daniel Polani, Mikhail Prokop...
Background: Multiple sequence alignment algorithms are very important tools in molecular biology today. Accurate alignment of proteins is central to several areas such as homology...
Saikat Chakrabarti, Nitin Bhardwaj, Prem A. Anand,...
Background: Quantitative descriptions of amino acid similarity, expressed as probabilistic models of evolutionary interchangeability, are central to many mainstream bioinformatic ...
Blazej Bulka, Marie desJardins, Stephen J. Freelan...
Background: In a previous report (La et al., Proteins, 2005), we have demonstrated that the identification of phylogenetic motifs, protein sequence fragments conserving the overal...