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BMCBI
2010
118views more  BMCBI 2010»
13 years 9 months ago
Towards realistic benchmarks for multiple alignments of non-coding sequences
Background: With the continued development of new computational tools for multiple sequence alignment, it is necessary today to develop benchmarks that aid the selection of the mo...
Jaebum Kim, Saurabh Sinha
BMCBI
2010
92views more  BMCBI 2010»
13 years 9 months ago
Integrating gene expression and GO classification for PCA by preclustering
Background: Gene expression data can be analyzed by summarizing groups of individual gene expression profiles based on GO annotation information. The mean expression profile per g...
Jorn R. de Haan, Ester Piek, René C. van Sc...
BMCBI
2010
109views more  BMCBI 2010»
13 years 9 months ago
Functional characterization and topological modularity of molecular interaction networks
Background: Analyzing interaction networks for functional characterization poses significant challenges arising from the noisy, incomplete, and generic nature of both the interact...
Jayesh Pandey, Mehmet Koyutürk, Ananth Grama
BMCBI
2008
142views more  BMCBI 2008»
13 years 9 months ago
Genetic weighted k-means algorithm for clustering large-scale gene expression data
Background: The traditional (unweighted) k-means is one of the most popular clustering methods for analyzing gene expression data. However, it suffers three major shortcomings. It...
Fang-Xiang Wu
BMCBI
2007
152views more  BMCBI 2007»
13 years 9 months ago
A cross-species alignment tool (CAT)
Background: The main two sorts of automatic gene annotation frameworks are ab initio and alignment-based, the latter splitting into two sub-groups. The first group is used for int...
Heng Li, Liang Guan, Tao Liu, Yiran Guo, Wei-Mou Z...