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WORM
2004
13 years 11 months ago
Preliminary results using scale-down to explore worm dynamics
A major challenge when attempting to analyze and model large-scale Internet phenomena such as the dynamics of global worm propagation is finding ate abstractions that allow us to ...
Nicholas Weaver, Ihab Hamadeh, George Kesidis, Ver...
ALMOB
2007
151views more  ALMOB 2007»
13 years 10 months ago
Local sequence alignments statistics: deviations from Gumbel statistics in the rare-event tail
Background: The optimal score for ungapped local alignments of infinitely long random sequences is known to follow a Gumbel extreme value distribution. Less is known about the imp...
Stefan Wolfsheimer, Bernd Burghardt, Alexander K. ...
BMCBI
2010
156views more  BMCBI 2010»
13 years 10 months ago
Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments
Background: High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical question...
James H. Bullard, Elizabeth Purdom, Kasper D. Hans...
BMCBI
2007
120views more  BMCBI 2007»
13 years 10 months ago
Re-sampling strategy to improve the estimation of number of null hypotheses in FDR control under strong correlation structures
Background: When conducting multiple hypothesis tests, it is important to control the number of false positives, or the False Discovery Rate (FDR). However, there is a tradeoff be...
Xin Lu, David L. Perkins
BMCBI
2010
151views more  BMCBI 2010»
13 years 10 months ago
Misty Mountain clustering: application to fast unsupervised flow cytometry gating
Background: There are many important clustering questions in computational biology for which no satisfactory method exists. Automated clustering algorithms, when applied to large,...
István P. Sugár, Stuart C. Sealfon