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BMCBI
2010
88views more  BMCBI 2010»
13 years 7 months ago
Proteome scanning to predict PDZ domain interactions using support vector machines
Background: PDZ domains mediate protein-protein interactions involved in important biological processes through the recognition of short linear motifs in their target proteins. Tw...
Shirley Hui, Gary D. Bader
BMCBI
2010
208views more  BMCBI 2010»
13 years 7 months ago
Calculation of accurate small angle X-ray scattering curves from coarse-grained protein models
Background: Genome sequencing projects have expanded the gap between the amount of known protein sequences and structures. The limitations of current high resolution structure det...
Kasper Stovgaard, Christian Andreetta, Jesper Ferk...
BMCBI
2006
165views more  BMCBI 2006»
13 years 7 months ago
Improving the quality of protein structure models by selecting from alignment alternatives
Background: In the area of protein structure prediction, recently a lot of effort has gone into the development of Model Quality Assessment Programs (MQAPs). MQAPs distinguish hig...
Ingolf Sommer, Stefano Toppo, Oliver Sander, Thoma...
CORR
2006
Springer
153views Education» more  CORR 2006»
13 years 7 months ago
Genetic Programming, Validation Sets, and Parsimony Pressure
Fitness functions based on test cases are very common in Genetic Programming (GP). This process can be assimilated to a learning task, with the inference of models from a limited n...
Christian Gagné, Marc Schoenauer, Marc Pari...
BMCBI
2007
120views more  BMCBI 2007»
13 years 7 months ago
Quantitative sequence-function relationships in proteins based on gene ontology
Background: The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs share function...
Vineet Sangar, Daniel J. Blankenberg, Naomi Altman...