Sciweavers

89 search results - page 4 / 18
» The meaning of alignment: lessons from structural diversity
Sort
View
BMCBI
2004
177views more  BMCBI 2004»
13 years 7 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
IJSWIS
2007
113views more  IJSWIS 2007»
13 years 7 months ago
A Formal Foundation for Ontology-Alignment Interaction Models
Ontology alignment foundations are hard to find in the literature. The abstract nature of the topic and the diverse means of practice make it difficult to capture it in a universal...
W. Marco Schorlemmer, Yannis Kalfoglou, Manuel Ate...
JCB
2008
106views more  JCB 2008»
13 years 7 months ago
Statistics of Random Protein Superpositions: p-Values for Pairwise Structure Alignment
Quantification of statistical significance is essential for the interpretation of protein structural similarity. To address this, a random model for protein structure comparison w...
James O. Wrabl, Nick V. Grishin
BIOINFORMATICS
2011
13 years 2 months ago
Integrative network alignment reveals large regions of global network similarity in yeast and human
Motivation: High-throughput methods for detecting molecular interactions have produced large sets of biological network data with much more yet to come. Analogous to sequence alig...
Oleksii Kuchaiev, Natasa Przulj
JCC
2008
88views more  JCC 2008»
13 years 7 months ago
A self-organizing algorithm for molecular alignment and pharmacophore development
Abstract: We present a method for simultaneous three-dimensional (3D) structure generation and pharmacophorebased alignment using a self-organizing algorithm called Stochastic Prox...
Deepak Bandyopadhyay, Dimitris K. Agrafiotis