Background: Correct temporal and spatial gene expression during metazoan development relies on combinatorial interactions between different transcription factors. As a consequence...
Background: RNA metabolism, through 'combinatorial splicing', can generate enormous structural diversity in the proteome. Alternative domains may interact, however, with...
Mark C. Emerick, Giovanni Parmigiani, William S. A...
In this talk we present a unified Variable Neighborhood Search (VNS) algorithm for the Capacitated Arc Routing Problem (CARP) and some of its variants - the Capacitated Arc Routin...
Michael Polacek, Karl F. Doerner, Richard F. Hartl...
Background: Designing novel proteins with site-directed recombination has enormous prospects. By locating effective recombination sites for swapping sequence parts, the probabilit...
One of the most important, common and critical management issues lies in determining the "best" project portfolio out of a given set of investment proposals. As this dec...
Karl F. Doerner, Walter J. Gutjahr, Richard F. Har...