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BMCBI
2008
120views more  BMCBI 2008»
13 years 8 months ago
A protein interaction based model for schizophrenia study
Background: Schizophrenia is a complex disease with multiple factors contributing to its pathogenesis. In addition to environmental factors, genetic factors may also increase susc...
Pei-Chun Hsu, Ueng-Cheng Yang, Kuan-Hui Shih, Chih...
ALMOB
2006
155views more  ALMOB 2006»
13 years 8 months ago
A phylogenetic generalized hidden Markov model for predicting alternatively spliced exons
Background: An important challenge in eukaryotic gene prediction is accurate identification of alternatively spliced exons. Functional transcripts can go undetected in gene expres...
Jonathan E. Allen, Steven L. Salzberg
BMCBI
2006
131views more  BMCBI 2006»
13 years 8 months ago
Hybridization interactions between probesets in short oligo microarrays lead to spurious correlations
Background: Microarrays measure the binding of nucleotide sequences to a set of sequence specific probes. This information is combined with annotation specifying the relationship ...
Michal J. Okoniewski, Crispin J. Miller
BMCBI
2008
128views more  BMCBI 2008»
13 years 8 months ago
Meta-analysis of breast cancer microarray studies in conjunction with conserved cis-elements suggest patterns for coordinate reg
Background: Gene expression measurements from breast cancer (BrCa) tumors are established clinical predictive tools to identify tumor subtypes, identify patients showing poor/good...
David D. Smith, Pål Sætrom, Ola R. Sn&...
BMCBI
2010
165views more  BMCBI 2010»
13 years 8 months ago
Filtering, FDR and power
Background: In high-dimensional data analysis such as differential gene expression analysis, people often use filtering methods like fold-change or variance filters in an attempt ...
Maarten van Iterson, Judith M. Boer, Renée ...