A protein interaction based model for schizophrenia study

Background: Schizophrenia is a complex disease with multiple factors contributing to its pathogenesis. In addition to environmental factors, genetic factors may also increase susceptibility. In other words, schizophrenia is a highly heritable disease. Some candidate genes have been deduced on the basis of their known function with others found on the basis of chromosomal location. Individuals with multiple candidate genes may have increased risk. However it is not clear what kind of gene combinations may produce the disease phenotype. Their collective effect remains to be studied. Results: Most pathways except metabolic pathways are rich in protein-protein interactions (PPIs). Thus, the PPI network contains pathway information, even though the upstream-downstream relation of PPI is yet to be explored. Here we have constructed a PPI sub-network by extracting the nearest neighbour of the 36 reported candidate genes described in the literature. Although these candidate genes were discove...

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Pei-Chun Hsu, Ueng-Cheng Yang, Kuan-Hui Shih, Chih-Min Liu, Yu-Li Liu, Hai-Gwo Hwu
• Keywords: BMCBI 2008, Candidate Genes, Protein, Protein Interaction