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BMCBI
2010
162views more  BMCBI 2010»
13 years 9 months ago
SNP-RFLPing 2: an updated and integrated PCR-RFLP tool for SNP genotyping
Background: PCR-restriction fragment length polymorphism (RFLP) assay is a cost-effective method for SNP genotyping and mutation detection, but the manual mining for restriction e...
Hsueh-Wei Chang, Yu-Huei Cheng, Li-Yeh Chuang, Che...
BMCBI
2010
107views more  BMCBI 2010»
13 years 9 months ago
Conditional random pattern model for copy number aberration detection
Background: DNA copy number aberration (CNA) is very important in the pathogenesis of tumors and other diseases. For example, CNAs may result in suppression of anti-oncogenes and ...
Fuhai Li, Xiaobo Zhou, Wanting Huang, Chung-Che Ch...
BMCBI
2007
124views more  BMCBI 2007»
13 years 9 months ago
BioInfer: a corpus for information extraction in the biomedical domain
Background: Lately, there has been a great interest in the application of information extraction methods to the biomedical domain, in particular, to the extraction of relationship...
Sampo Pyysalo, Filip Ginter, Juho Heimonen, Jari B...
BMCBI
2010
135views more  BMCBI 2010»
13 years 9 months ago
Integration and visualization of systems biology data in context of the genome
Background: High-density tiling arrays and new sequencing technologies are generating rapidly increasing volumes of transcriptome and protein-DNA interaction data. Visualization a...
J. Christopher Bare, Tie Koide, David J. Reiss, Da...
BMCBI
2008
145views more  BMCBI 2008»
13 years 9 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...