We introduce, analyze and demonstrate a recursive hierarchical generalization of the widely used hidden Markov models, which we name Hierarchical Hidden Markov Models (HHMM). Our m...
Background: Genome databases contain diverse kinds of information, including gene annotations and nucleotide and amino acid sequences. It is not easy to integrate such information...
Background: In Archeae and Bacteria, the repeated elements called CRISPRs for "clustered regularly interspaced short palindromic repeats" are believed to participate in ...
In this paper we use doubly stochastic matrices to establish a link between Birkhoff polytopes and heat kernels on graphs. Based on this analysis we construct a multi-dimensional ...
Francisco Escolano, Edwin R. Hancock, Miguel Angel...
Pise is interface construction software for bioinformatics applications that run by commandline operations. It creates common, easy to use interfaces to these for the Web, or othe...