820 search results - page 33 / 164 » Using Multiple Alignments to Improve Gene Prediction |
BIBE
2006
IEEE
14 years 1 months ago
2006
IEEE
DNA sequence alignment is a critical step in identifying homology between organisms. The most widely used alignment program, ClustalW, is known to suffer from the local minima pro...
BMCBI
2007
13 years 7 months ago
2007
Background: Profile Hidden Markov Models (HMM) are statistical representations of protein families derived from patterns of sequence conservation in multiple alignments and have b...
BMCBI
2008
13 years 7 months ago
2008
Background: The accurate detection of differentially expressed (DE) genes has become a central task in microarray analysis. Unfortunately, the noise level and experimental variabi...
BMCBI
2007
13 years 7 months ago
2007
Background: Many crucial cellular operations such as metabolism, signalling, and regulations are based on protein-protein interactions. However, the lack of robust protein-protein...
TCBB
2010
13 years 5 months ago
2010
—The correct interpretation of many molecular biology experiments depends in an essential way on the accuracy and consistency of the existing annotation databases. Such databases...