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» Using Multiple Alignments to Improve Gene Prediction
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BMCBI
2011
12 years 11 months ago
Cell Subset Prediction for Blood Genomic Studies
Background: Genome-wide transcriptional profiling of patient blood samples offers a powerful tool to investigate underlying disease mechanisms and personalized treatment decisions...
Christopher R. Bolen, Mohamed Uduman, Steven H. Kl...
BMCBI
2004
150views more  BMCBI 2004»
13 years 7 months ago
Cross-species comparison significantly improves genome-wide prediction of cis-regulatory modules in Drosophila
Background: The discovery of cis-regulatory modules in metazoan genomes is crucial for understanding the connection between genes and organism diversity. It is important to quanti...
Saurabh Sinha, Mark D. Schroeder, Ulrich Unnerstal...
BMCBI
2004
154views more  BMCBI 2004»
13 years 7 months ago
Base-By-Base: Single nucleotide-level analysis of whole viral genome alignments
Background: With ever increasing numbers of closely related virus genomes being sequenced, it has become desirable to be able to compare two genomes at a level more detailed than ...
Ryan Brodie, Alex J. Smith, Rachel L. Roper, Vasil...
BMCBI
2007
142views more  BMCBI 2007»
13 years 7 months ago
Predicting and improving the protein sequence alignment quality by support vector regression
Background: For successful protein structure prediction by comparative modeling, in addition to identifying a good template protein with known structure, obtaining an accurate seq...
Minho Lee, Chan-seok Jeong, Dongsup Kim
NAR
2007
124views more  NAR 2007»
13 years 6 months ago
The RNAz web server: prediction of thermodynamically stable and evolutionarily conserved RNA structures
Many non-coding RNA genes and cis-acting regulatory elements of mRNAs contain RNA secondary structures that are critical for their function. Such functional RNAs can be predicted ...
Andreas R. Gruber, Richard Neuböck, Ivo L. Ho...