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» Using Multiple Alignments to Improve Gene Prediction
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159
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BMCBI
2007
141views more  BMCBI 2007»
15 years 3 months ago
Reconstruction of human protein interolog network using evolutionary conserved network
Background: The recent increase in the use of high-throughput two-hybrid analysis has generated large quantities of data on protein interactions. Specifically, the availability of...
Tao-Wei Huang, Chung-Yen Lin, Cheng-Yan Kao
116
Voted
ACL
2007
15 years 5 months ago
Learning Predictive Structures for Semantic Role Labeling of NomBank
This paper presents a novel application of Alternating Structure Optimization (ASO) to the task of Semantic Role Labeling (SRL) of noun predicates in NomBank. ASO is a recently pr...
Chang Liu, Hwee Tou Ng
121
Voted
BMCBI
2010
139views more  BMCBI 2010»
15 years 3 months ago
CMASA: an accurate algorithm for detecting local protein structural similarity and its application to enzyme catalytic site anno
Background: The rapid development of structural genomics has resulted in many "unknown function" proteins being deposited in Protein Data Bank (PDB), thus, the functiona...
Gong-Hua Li, Jing-Fei Huang
117
Voted
BMCBI
2010
109views more  BMCBI 2010»
15 years 3 months ago
Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model
Background: The binding of peptide fragments of extracellular peptides to class II MHC is a crucial event in the adaptive immune response. Each MHC allotype generally binds a dist...
Andrew J. Bordner, Hans D. Mittelmann
151
Voted
BMCBI
2008
147views more  BMCBI 2008»
15 years 3 months ago
Transmembrane helix prediction using amino acid property features and latent semantic analysis
Background: Prediction of transmembrane (TM) helices by statistical methods suffers from lack of sufficient training data. Current best methods use hundreds or even thousands of f...
Madhavi Ganapathiraju, Narayanas Balakrishnan, Raj...