Tools for the identification of trans-membrane spans from the protein sequence are widely used in the experimental community. Computational structural biology seeks to increase the...
Background: It is well known that different species have different protein domain repertoires, and indeed that some protein domains are kingdom specific. This information has not ...
Lachlan James M. Coin, Alex Bateman, Richard Durbi...
Background: Structural variations caused by a wide range of physico-chemical and biological sources directly influence the function of a protein. For enzymatic proteins, the struc...
Drew H. Bryant, Mark Moll, Brian Y. Chen, Viachesl...
Homology identification is the first step for many genomic studies. Current methods, based on sequence comparison, can result in a substantial number of mis-assignments due to the ...