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BMCBI
2007
126views more  BMCBI 2007»
13 years 8 months ago
Using gene expression data and network topology to detect substantial pathways, clusters and switches during oxygen deprivation
Background: Biochemical investigations over the last decades have elucidated an increasingly complete image of the cellular metabolism. To derive a systems view for the regulation...
Gunnar Schramm, Marc Zapatka, Roland Eils, Rainer ...
BMCBI
2007
102views more  BMCBI 2007»
13 years 8 months ago
Setting up a large set of protein-ligand PDB complexes for the development and validation of knowledge-based docking algorithms
Background: The number of algorithms available to predict ligand-protein interactions is large and ever-increasing. The number of test cases used to validate these methods is usua...
Luis A. Diago, Persy Morell, Longendri Aguilera, E...
BMCBI
2007
124views more  BMCBI 2007»
13 years 8 months ago
Protein structural similarity search by Ramachandran codes
Background: Protein structural data has increased exponentially, such that fast and accurate tools are necessary to access structure similarity search. To improve the search speed...
Wei-Cheng Lo, Po-Jung Huang, Chih-Hung Chang, Ping...
BMCBI
2007
107views more  BMCBI 2007»
13 years 8 months ago
A computational approach for detecting peptidases and their specific inhibitors at the genome level
Background: Peptidases are proteolytic enzymes responsible for fundamental cellular activities in all organisms. Apparently about 2–5% of the genes encode for peptidases, irresp...
Lisa Bartoli, Remo Calabrese, Piero Fariselli, Dam...
FSS
2006
140views more  FSS 2006»
13 years 8 months ago
Advances and challenges in interval-valued fuzzy logic
Among the various extensions to the common [0, 1]-valued truth degrees of "traditional" fuzzy set theory, closed intervals of [0, 1] stand out as a particularly appealin...
Chris Cornelis, Glad Deschrijver, Etienne E. Kerre