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» Visualization of Gene Combinations
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BMCBI
2007
104views more  BMCBI 2007»
13 years 10 months ago
Joint mapping of genes and conditions via multidimensional unfolding analysis
Background: Microarray compendia profile the expression of genes in a number of experimental conditions. Such data compendia are useful not only to group genes and conditions base...
Katrijn Van Deun, Kathleen Marchal, Willem J. Heis...
RECOMB
2008
Springer
14 years 10 months ago
Detecting Disease-Specific Dysregulated Pathways Via Analysis of Clinical Expression Profiles
We present a method for identifying connected gene subnetworks significantly enriched for genes that are dysregulated in specimens of a disease. These subnetworks provide a signat...
Igor Ulitsky, Richard M. Karp, Ron Shamir
GCB
2005
Springer
98views Biometrics» more  GCB 2005»
14 years 3 months ago
Composite Module Analyst: A Fitness-Based Tool for Prediction of Transcription Regulation
: Functionally related genes involved in the same molecular-genetic, biochemical, or physiological process are often regulated coordinately Such regulation is provided by precisely...
Alexander E. Kel, Tatiana Konovalova, Tagir Valeev...
BMCBI
2008
151views more  BMCBI 2008»
13 years 10 months ago
An integrated database-pipeline system for studying single nucleotide polymorphisms and diseases
Background: Studies on the relationship between disease and genetic variations such as single nucleotide polymorphisms (SNPs) are important. Genetic variations can cause disease b...
Jin Ok Yang, Sohyun Hwang, Jeongsu Oh, Jong Bhak, ...
BMCBI
2006
119views more  BMCBI 2006»
13 years 10 months ago
LS-NMF: A modified non-negative matrix factorization algorithm utilizing uncertainty estimates
Background: Non-negative matrix factorisation (NMF), a machine learning algorithm, has been applied to the analysis of microarray data. A key feature of NMF is the ability to iden...
Guoli Wang, Andrew V. Kossenkov, Michael F. Ochs