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BMCBI
2007
200views more  BMCBI 2007»
13 years 10 months ago
Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data
Background: Genomic deletions and duplications are important in the pathogenesis of diseases, such as cancer and mental retardation, and have recently been shown to occur frequent...
Ágnes Baross, Allen D. Delaney, H. Irene Li...
IEEEMM
2007
146views more  IEEEMM 2007»
13 years 9 months ago
Learning Microarray Gene Expression Data by Hybrid Discriminant Analysis
— Microarray technology offers a high throughput means to study expression networks and gene regulatory networks in cells. The intrinsic nature of high dimensionality and small s...
Yijuan Lu, Qi Tian, Maribel Sanchez, Jennifer L. N...
BMCBI
2006
181views more  BMCBI 2006»
13 years 10 months ago
Array2BIO: from microarray expression data to functional annotation of co-regulated genes
Background: There are several isolated tools for partial analysis of microarray expression data. To provide an integrative, easy-to-use and automated toolkit for the analysis of A...
Gabriela G. Loots, Patrick S. G. Chain, Shalini Ma...
BMCBI
2004
117views more  BMCBI 2004»
13 years 9 months ago
Cancer characterization and feature set extraction by discriminative margin clustering
Background: A central challenge in the molecular diagnosis and treatment of cancer is to define a set of molecular features that, taken together, distinguish a given cancer, or ty...
Kamesh Munagala, Robert Tibshirani, Patrick O. Bro...
BMCBI
2010
131views more  BMCBI 2010»
13 years 10 months ago
Prediction of epigenetically regulated genes in breast cancer cell lines
Background: Methylation of CpG islands within the DNA promoter regions is one mechanism that leads to aberrant gene expression in cancer. In particular, the abnormal methylation o...
Leandro A. Loss, Anguraj Sadanandam, Steffen Durin...