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BMCBI
2011
13 years 2 months ago
Accurate statistics for local sequence alignment with position-dependent scoring by rare-event sampling
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
Stefan Wolfsheimer, Inke Herms, Sven Rahmann, Alex...
RECOMB
2001
Springer
14 years 8 months ago
Finding motifs using random projections
motif discovery problem abstracts the task of discovering short, conserved sites in genomic DNA. Pevzner and Sze recently described a precise combinatorial formulation of motif di...
Jeremy Buhler, Martin Tompa
TIT
1998
96views more  TIT 1998»
13 years 7 months ago
Sequential Prediction of Individual Sequences Under General Loss Functions
Abstract— We consider adaptive sequential prediction of arbitrary binary sequences when the performance is evaluated using a general loss function. The goal is to predict on each...
David Haussler, Jyrki Kivinen, Manfred K. Warmuth
BMCBI
2007
102views more  BMCBI 2007»
13 years 8 months ago
A comprehensive system for evaluation of remote sequence similarity detection
Background: Accurate and sensitive performance evaluation is crucial for both effective development of better structure prediction methods based on sequence similarity, and for th...
Yuan Qi, Ruslan Sadreyev, Yong Wang, Bong-Hyun Kim...
BMCBI
2006
124views more  BMCBI 2006»
13 years 8 months ago
Predicting transcription factor binding sites using local over-representation and comparative genomics
Background: Identifying cis-regulatory elements is crucial to understanding gene expression, which highlights the importance of the computational detection of overrepresented tran...
Matthieu Defrance, Hélène Touzet